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Abstract #3961

MRI-based parenchyma CSF fraction (CSFF) mapping is a potential biomarker of brain drainage function: a multimodal imaging study

Liangdong Zhou1, Thanh Nguyen1, and Yi Li1
1Radiology, Weill Cornell Medicine, New York, NY, United States


We demonstrated that, our proposed T2 relaxometry-based free water mapping, CSFF, could be an imaging biomarker of dilated PVS and CSF clearance function by correlating it with multiple brain clearance-related measures including PVS score, PC-MRI based aqueduct CSF flow, dynamic PET based ventricle CSF clearance, amyloid beta and tau deposits. Our results show that CSFF is positively associated with PVS score, aging, amyloid beta and tau deposits. And it negatively correlates with net aqueduct CSF flow, ventricle CSF flow, and cognitive score.

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