We demonstrated that, our proposed T2 relaxometry-based free water mapping, CSFF, could be an imaging biomarker of dilated PVS and CSF clearance function by correlating it with multiple brain clearance-related measures including PVS score, PC-MRI based aqueduct CSF flow, dynamic PET based ventricle CSF clearance, amyloid beta and tau deposits. Our results show that CSFF is positively associated with PVS score, aging, amyloid beta and tau deposits. And it negatively correlates with net aqueduct CSF flow, ventricle CSF flow, and cognitive score.
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