Abstract #3962

Resting-state functional networks in normal aging and asymptomatic Alzheimer's disease

Junjie Wu¹, Qixiang Lin², Benjamin B. Risk³, Aditya S. Bisht², David W. Loring², Felicia C. Goldstein², Allan I. Levey², James J. Lah², and Deqiang Qiu^1,4

¹Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, ²Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States, ³Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA, United States, ⁴Joint Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States

Synopsis

We systematically studied alterations in 14 resting-state functional networks due to normal aging and AD pathology in the asymptomatic phase, as well as their relationship with CSF biomarkers for AD and neuropsychological assessments. We found disrupted functional connectivity in most of the functional networks with normal aging and compromised left executive control network (LECN) due to asymptomatic AD pathology. Furthermore, LECN is associated with overall cognition. Tau closely correlates with functional networks in asymptomatic AD.

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