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Abstract #3962

Resting-state functional networks in normal aging and asymptomatic Alzheimer's disease

Junjie Wu1, Qixiang Lin2, Benjamin B. Risk3, Aditya S. Bisht2, David W. Loring2, Felicia C. Goldstein2, Allan I. Levey2, James J. Lah2, and Deqiang Qiu1,4
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States, 3Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA, United States, 4Joint Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States


We systematically studied alterations in 14 resting-state functional networks due to normal aging and AD pathology in the asymptomatic phase, as well as their relationship with CSF biomarkers for AD and neuropsychological assessments. We found disrupted functional connectivity in most of the functional networks with normal aging and compromised left executive control network (LECN) due to asymptomatic AD pathology. Furthermore, LECN is associated with overall cognition. Tau closely correlates with functional networks in asymptomatic AD.

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