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Abstract #3963

Studying cerebrospinal fluid bulk flow in mice using high-resolution dynamic macromolecular gadolinium enhanced MRI on a whole-body 3T system

Wingchi Edmund Kwok1, Molly Brady2, Akib Rahman3, Alexander Solorzano3, Ronald Wood3, and Rashid Deane3
1Imaging Sciences, University of Rochester Medical Center, Rochester, NY, United States, 2Tufts University, Boston, MA, United States, 3University of Rochester, Rochester, NY, United States


Study of CSF flow can be used to assess CSF clearance pathways for the better understanding of neurological diseases, such as Alzheimer's disease. We developed a technique for macromolecular gadolinium enhanced dynamic MRI of CSF in mice on a whole-body 3T system. A specially designed 4-channel RF receive coil was developed, and a high-resolution 3D spoiled gradient-echo T1 sequence was used. Gadolinium-albumin contrast was injected into the cisterna magna. Contrast enhancement was detected in various locations including the olfactory lobe, nasal cavity, lymphatic system and spine cord. Lower contrast elimination rates were observed in old mice than in young mice.

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