Study of CSF flow can be used to assess CSF clearance pathways for the better understanding of neurological diseases, such as Alzheimer's disease. We developed a technique for macromolecular gadolinium enhanced dynamic MRI of CSF in mice on a whole-body 3T system. A specially designed 4-channel RF receive coil was developed, and a high-resolution 3D spoiled gradient-echo T1 sequence was used. Gadolinium-albumin contrast was injected into the cisterna magna. Contrast enhancement was detected in various locations including the olfactory lobe, nasal cavity, lymphatic system and spine cord. Lower contrast elimination rates were observed in old mice than in young mice.
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