Abstract #3964

In vivo mapping of hippocampal venous vasculature and oxygen saturation using dual-echo SWI/QSM on 7T: a potential marker for neurodegeneration

Chenyang Li¹, Li Jiang¹, Marco Muccio¹, Sagar Buch², Hanzhang Lu³, E.Mark Haacke², and Yulin Ge¹

¹Department of Radiology, NYU Grossman School of Medicine, New York, NY, United States, ²Department of Radiology, Wayne State University School of Medicine, Detroit, MI, United States, ³Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

In this study, we reconstructed the venous drainage course of Basal vein of Rosenthal (BVR) and its tributaries using dual-echo SWI/QSM. Consistent with existing knowledge of venous anatomy, our results show that BVR drains blood from multiple tissue structures such as insula, amygdala and hippocampus. Inferior ventricular vein (IVV) and medial atrial vein (MAV), two tributaries of BVR, are anatomically relevant to the venous drainage in hippocampus. With the proposed technique, we extracted the venous blood susceptibility value in BVR and IVV/MAV to examine its feasibility in characterizing changes of venous oxygenation level related to hippocampal neurodegeneration.

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