Preoperative 7T MRI relates to medication dose reduction after chronic deep brain stimulation for Parkinson’s disease
Sharmaine Khanna1, Amirah Johnson1, Isyss Lyons1, Ben Sipes1, Olga Tymofiyeva1, Janine Lupo1, Jill Ostrem2, Doris Wang3, Philip Starr3, Ian Bledsoe2, and Melanie Morrison1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Neurology, University of California San Francisco, San Francisco, CA, United States, 3Neurological Surgery, University of California San Francisco, San Francisco, CA, United States
Robust objective markers that can predict an individual Parkinson’s disease (PD) patient's potential response to brain stimulation (DBS) are limited. Here we evaluate the relationship between preoperative multimodal 7T MR metrics and a surrogate measure of motor response to DBS: the pre-to-post change in daily dose of dopamine medications. We found that fMRI signal variability in the superior sensorimotor network was more strongly correlated with medication dose reduction after DBS than current clinical prognostic criteria. Brain iron accumulation in the globus pallidus interna furthermore discriminated patients who did versus did not experience a dose change.
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