Abstract #3968

Preoperative 7T MRI relates to medication dose reduction after chronic deep brain stimulation for Parkinson’s disease

Sharmaine Khanna¹, Amirah Johnson¹, Isyss Lyons¹, Ben Sipes¹, Olga Tymofiyeva¹, Janine Lupo¹, Jill Ostrem², Doris Wang³, Philip Starr³, Ian Bledsoe², and Melanie Morrison¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Neurology, University of California San Francisco, San Francisco, CA, United States, ³Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

Synopsis

Robust objective markers that can predict an individual Parkinson’s disease (PD) patient's potential response to brain stimulation (DBS) are limited. Here we evaluate the relationship between preoperative multimodal 7T MR metrics and a surrogate measure of motor response to DBS: the pre-to-post change in daily dose of dopamine medications. We found that fMRI signal variability in the superior sensorimotor network was more strongly correlated with medication dose reduction after DBS than current clinical prognostic criteria. Brain iron accumulation in the globus pallidus interna furthermore discriminated patients who did versus did not experience a dose change.

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