Robust objective markers that can predict an individual Parkinson’s disease (PD) patient's potential response to brain stimulation (DBS) are limited. Here we evaluate the relationship between preoperative multimodal 7T MR metrics and a surrogate measure of motor response to DBS: the pre-to-post change in daily dose of dopamine medications. We found that fMRI signal variability in the superior sensorimotor network was more strongly correlated with medication dose reduction after DBS than current clinical prognostic criteria. Brain iron accumulation in the globus pallidus interna furthermore discriminated patients who did versus did not experience a dose change.
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