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Abstract #3969

Glutathione MRS of the Substantia Nigra in Parkinson Disease

Adil Bashir1, Frank M Skidmore2, and Thomas S Denney1
1Electrical & Computer Engineering, Auburn University, Auburn, AL, United States, 2Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States


Glutathione in brain provides protection from oxidative stress. Autopsy studies have shown that glutathione levels are significantly reduced in substantia nigra of patients with Parkinson disease. In this study, we demonstrate the measurement of glutathione with MR spectroscopy in the human substantia nigra in vivo at 7T. Short echo-time STEAM pulse sequence was used to obtain high SNR spectra from Parkinson disease patients and healthy controls. Measured glutathione levels were significantly lower in patients when compared to healthy individuals.

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