Abstract #3970

Decreased Myelin Content on Myelin Water Imaging and Correlation with Cognitive Performance in Adults with Perinatal HIV

Payal Patel¹, Alyssa Vecchio², Peter Chen³, Jennifer Chiarella⁴, Shannon Kolind⁵, Michael Hoff¹, Adam Dvorak⁶, Irene Vavasour⁵, Serena Spudich⁴, Christina Marra¹, Robert Paul⁷, and Swati Rane¹

¹University of Washington, Seattle, WA, United States, ²University of New Mexico, Albuquerque, NM, United States, ³Albert Einstein College of Medicine, Bronx, NY, United States, ⁴Yale University, New Haven, CT, United States, ⁵University of British Columbia, Vancouver, BC, Canada, ⁶University of British Columbia, Vancouver, BC, United States, ⁷Missouri Institute of Mental Health, St. Louis, MO, United States

Synopsis

Little is known about the pathology of cerebral white matter injury occurring in HIV. Myelin water imaging quantifies myelin content and results are expressed as myelin water fraction (MWF). We defined the cognitive profile of virally suppressed adults with perinatally acquired HIV (pHIV) and demonstrate the association between MWF and cognition. Ten (58%) adults with pHIV were cognitively impaired. Lower global MWF correlated with worse performance in executive function (r: 0.762, p: 0.037). Cognitive impairment is common among our cohort of adults with virally suppressed pHIV. Decreased myelination occurs in pHIV and may be a pathologic substrate of cognitive impairment.

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