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Abstract #3970

Decreased Myelin Content on Myelin Water Imaging and Correlation with Cognitive Performance in Adults with Perinatal HIV

Payal Patel1, Alyssa Vecchio2, Peter Chen3, Jennifer Chiarella4, Shannon Kolind5, Michael Hoff1, Adam Dvorak6, Irene Vavasour5, Serena Spudich4, Christina Marra1, Robert Paul7, and Swati Rane1
1University of Washington, Seattle, WA, United States, 2University of New Mexico, Albuquerque, NM, United States, 3Albert Einstein College of Medicine, Bronx, NY, United States, 4Yale University, New Haven, CT, United States, 5University of British Columbia, Vancouver, BC, Canada, 6University of British Columbia, Vancouver, BC, United States, 7Missouri Institute of Mental Health, St. Louis, MO, United States


Little is known about the pathology of cerebral white matter injury occurring in HIV. Myelin water imaging quantifies myelin content and results are expressed as myelin water fraction (MWF). We defined the cognitive profile of virally suppressed adults with perinatally acquired HIV (pHIV) and demonstrate the association between MWF and cognition. Ten (58%) adults with pHIV were cognitively impaired. Lower global MWF correlated with worse performance in executive function (r: 0.762, p: 0.037). Cognitive impairment is common among our cohort of adults with virally suppressed pHIV. Decreased myelination occurs in pHIV and may be a pathologic substrate of cognitive impairment.

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