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Abstract #3971

Voxel-based assessment of volumetric brain differences in patients with premanifest and early manifest Huntington’s disease

Melanie Morrison1, Angela Jakary1, Andrew Leynes1, Jingwen Yao1, Julia Glueck2, Theresa Driscoll2, Joseph Talkakson2, Alexandra Nelson2, Katherine Possin2, Michael Geschwind2, Christopher Hess1, and Janine Lupo1
1Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Neurology, University of California San Francisco, San Francisco, CA, United States


More robust and accurate methods are needed to characterize disease extent and progression of Huntington's disease in order to develop disease-modifying therapies. Here we used voxel-based morphometry to evaluate patterns of regional brain atrophy in premanifest and early manifest HD patients relative to healthy controls. We found typical wide-spread sub-cortical and cortical gray matter atrophy in early manifest patients and observed similar though less pronounced atrophy in premanifest patients. As the presence of volume loss prior to symptom onset remains controversial, this work contributes to existing evidence of atrophy initiating as early as the premanifest disease stage.

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