Abstract #3972

Investigation of Blood-Brain Barrier Disruption in Schizophrenia using Magnetization Transfer-ASL at 7T.

Sultan Zaman Mahmud¹, Adrienne Lahti², Nina V. Kraguljac², Thomas S. Denney¹, and Adil Bashir¹

¹Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, ²Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL, United States

Synopsis

Schizophrenia (SCZ) is a central nervous system (CNS) disease which is characterized by thinking disorder, cognitive impairments and other clinical manifestations that alter daily functioning. SCZ currently does not have satisfactory treatment options to improve cognitive symptoms. Deeper understanding of the underlying mechanism is required for effective treatment of SCZ. Blood-brain barrier (BBB) is the immunological junction between brain and vascular circulation, and its disruption is associated with a number of CNS diseases. This study aims to investigate if the BBB is compromised in SCZ.

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