Visual Cortex Bioenergetic Abnormalities in Schizophrenia
Adil Bashir1, Adrienne C Lahti2, Nina Kraguljac2, and Thomas S Denney1
1Electrical & Computer Engineering, Auburn University, Auburn, AL, United States, 2Psychiatry and Behavioral Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, United States
This study measured high energy metabolite ratios and CK and ATP metabolic reaction rate in visual cortex of SZ patients and HCs. The forward rate constant hence ATP production flux through CK enzyme was significantly lower in SZ patients when compared to age/sex matched controls. We did not observe abnormalities in metabolite concentration. Impaired CK reaction may underlie abnormal neuro function and information processing in SZ.
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