We used 1H MRS at 4 T to quantify NAA concentrations and apparent T2 relaxation times in 104 psychosis patients compared to 50 matched healthy controls with four TEs (TE = 30, 90, 150 and 200 ms). Even at short TE (30 ms), NAA concentration without T2 correction was significantly lower in chronic psychosis compared to age-matched healthy controls. After T2 correction, no significant differences remained. Thus, it may be neuronal microenvironment indexed by T2 relaxation time, but not neuronal integrity indexed by NAA concentration that underlies the widely reported NAA concentration reductions in psychotic disorders.
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