Numerous studies have analyzed morphological measurements to better understand how depression alters the brain, but few studies have explored curvature as a potential biomarker. By analyzing data from 7T MRI scans, we aimed to determine whether curvature measurements can differentiate between MDD patients and controls. We performed generalized linear models to analyze the relationship between participants’ status and measurements for intrinsic curvature index, Gaussian curvature, mean curvature, and folding index in thirty-four brain regions. Six regions showed significantly higher measures of curvature in MDD patients: the inferior temporal, pars triangularis, supramarginal, lateral orbitofrontal, isthmus cingulate, and entorhinal.
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