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Abstract #3976

Quantitative MRI evaluation of reduced myelin content in white matter tracts in major depressive disorde

Masaya Misaki1, Aki Tsuchiyagaito1, Beni Mulyana1,2, Rayus Kuplicki1, and Martin Paulus1
1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Electrical and Computer Engineering, University of Oklahoma, Tulsa, OK, United States


Quantitative MRI (qMRI) of T1, T2, and proton density (PD) parameters can inform the brain's local microstructure, such as myelin content. We investigated the myelin alteration in white matter tracts for MDD participants compared to healthy controls by qMRI scanning using SyMRI software. MDD group had reduced myelin content in bilateral uncinate fasciculus, fornix, right external capsule, left tapetum, and genu of the corpus callosum regions. These results were consistent with previous reports about the white-matter microstructure alteration in MDD with diffusion tensor imaging (DTI). The results indicate that myelin measurement with qMRI can be an alternative to DTI.

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