Quantitative MRI (qMRI) of T1, T2, and proton density (PD) parameters can inform the brain's local microstructure, such as myelin content. We investigated the myelin alteration in white matter tracts for MDD participants compared to healthy controls by qMRI scanning using SyMRI software. MDD group had reduced myelin content in bilateral uncinate fasciculus, fornix, right external capsule, left tapetum, and genu of the corpus callosum regions. These results were consistent with previous reports about the white-matter microstructure alteration in MDD with diffusion tensor imaging (DTI). The results indicate that myelin measurement with qMRI can be an alternative to DTI.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords