For determination of dia- and paramagnetic sources, quantitative susceptibility mapping (QSM) of phase is combined with a R2* model of magnitude of multiecho gradient echo data, which is advantageous over R2’ model that requires additional T2 mapping, Magnetic source separation was performed in in vivo (17 multiple sclerosis (MS) patients) and ex vivo (a whole brain and 3 MS brain tissue blocks). Both R2* and R2’ methods were found to be well correlated in vivo data. R2* based positive and negative susceptibility sources estimation in ex vivo MS lesions correlated with optical density of lesion histology.
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