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Abstract #3978

Feasibility of $$$R_2^*$$$ /QSM susceptibility source separation for application in multiple sclerosis

Alexey Dimov1, Thanh Nguyen1, Kelly Gillen1, Melanie Marcille2, Pascal Spincemaille1, Pitt David3, Susan Gauthier2, and Yi Wang1
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Neurology, Weill Cornell Medicine, New York, NY, United States, 3Neurology, Yale School of Medicine, New Haven, CT, United States


For determination of dia- and paramagnetic sources, quantitative susceptibility mapping (QSM) of phase is combined with a R2* model of magnitude of multiecho gradient echo data, which is advantageous over R2’ model that requires additional T2 mapping, Magnetic source separation was performed in in vivo (17 multiple sclerosis (MS) patients) and ex vivo (a whole brain and 3 MS brain tissue blocks). Both R2* and R2’ methods were found to be well correlated in vivo data. R2* based positive and negative susceptibility sources estimation in ex vivo MS lesions correlated with optical density of lesion histology.

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