Abstract #3979

Assessing Tissue Structure Differences Between RRMS and SPMS Patients Using Advanced Diffusion and MRI Texture Analysis

Olayinka Oladosu¹, Wei-Qiao Liu², Lenora Brown^2,3, Bruce Pike^2,3,4, Marcus Bruce Koch^2,3, Luanne Metz^2,3, and Yunyan Zhang^2,3,4

¹Neuroscience, University of Calgary, Calgary, AB, Canada, ²Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, ³Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ⁴Radiology, University of Calgary, Calgary, AB, Canada

Synopsis

Tissue structure changes underlying disease development and progression in MS are not fully understood. We investigated tissue structure in 29 RRMS and SPMS patients using advanced diffusion imaging and MRI texture measures using analyses over 3 spatial scales: white matter histogram analysis, tract ROI analysis, and along-tract statistics. We found that phase congruency texture analysis best differentiated RRMS and SPMS patients in histogram analysis. Diffusion measures differentiated the subtypes across all analyses in multiple tracts. The findings by advanced measures of tissue structure may further research into disease progression in MS.

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