Tissue structure changes underlying disease development and progression in MS are not fully understood. We investigated tissue structure in 29 RRMS and SPMS patients using advanced diffusion imaging and MRI texture measures using analyses over 3 spatial scales: white matter histogram analysis, tract ROI analysis, and along-tract statistics. We found that phase congruency texture analysis best differentiated RRMS and SPMS patients in histogram analysis. Diffusion measures differentiated the subtypes across all analyses in multiple tracts. The findings by advanced measures of tissue structure may further research into disease progression in MS.