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Abstract #3980

Association Between Common MRI Metrics of Disease Activity in MS and Spinal Cord Atrophy

Burcu Zeydan1,2,3, Nur Neyal1, Jiye Son2, Holly A. Morrison3, Elizabeth J. Atkinson4, John D. Port2,3, Kejal Kantarci2, and Orhun H. Kantarci1,3
1Neurology, Mayo Clinic, Rochester, MN, United States, 2Radiology, Mayo Clinic, Rochester, MN, United States, 3Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, United States, 4Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States


Cervical spinal cord atrophy is an important MRI measure that correlates with progressive MS. We have previously shown that the cranio-caudal loss of cervical cord area correlates with the evolution in MS disease continuum. In this prospective study, in addition to age, we showed that thalamic volumes may correlate with cervical cord area measurements, possibly through a Wallerian degeneration mechanism, while total brain lesion volumes do not. Our findings suggest that spinal cord area measurements in MS is potentially an independent metric from lesion load measurements but can be complemented by thalamic volume measurements as imaging outcomes in clinical trials.

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