Brain Oxygen Extraction Fraction in Patients with Normal Pressure Hydrocephalus
Hangwei Zhuang1,2, Junghun Cho2, Gloria Chia-Yi Chiang2, Ilhami Kovanlikaya2, Linda A Heier2, and Yi Wang1,2
1Biomedical Engineering, Cornell University, New York, NY, United States, 2Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States
Oxygen extraction fraction (OEF) maps were obtained from multi-echo gradient echo (mGRE) using a novel MRI biophysics model called QSM+qBOLD (QQ) in Normal Pressure Hydrocephalus (NPH) patients. OEF of the whole brain, cortical gray matter, caudate, and pallidum were significantly negatively correlated with ventricular volume. The finding demonstrates the feasibility of OEF mapping using MRI in NPH patients and suggests global and local neurodegeneration.
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