Oxygen extraction fraction (OEF) maps were obtained from multi-echo gradient echo (mGRE) using a novel MRI biophysics model called QSM+qBOLD (QQ) in Normal Pressure Hydrocephalus (NPH) patients. OEF of the whole brain, cortical gray matter, caudate, and pallidum were significantly negatively correlated with ventricular volume. The finding demonstrates the feasibility of OEF mapping using MRI in NPH patients and suggests global and local neurodegeneration.
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