Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: relationship to vascular and Alzheimer’s pathology
Zixuan Lin1, Chantelle Lim2, Dengrong Jiang1, Anja Soldan3, Corinne Pettigrew3, Kumiko Oishi1, Peiying Liu1,4, Marilyn Albert3, and Hanzhang Lu1
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States
Oxygen extraction fraction (OEF) has been suggested to be differentially affected by Alzheimer’s and vascular pathology in older adults. We aimed to investigate age-related OEF change with a longitudinal study design. 138 elderly participants were recruited with a 2-year follow-up. Individuals with higher vascular risks showed significant elevation in OEF but not those with lower vascular risks. Higher OEF was also associated with a faster growth in white matter hyperintensities, but not with any Alzheimer’s pathology or APOE gene. The results suggested a prominent effect of vascular pathology on OEF in aging.
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