Abstract #3984

Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: relationship to vascular and Alzheimer’s pathology

Zixuan Lin¹, Chantelle Lim², Dengrong Jiang¹, Anja Soldan³, Corinne Pettigrew³, Kumiko Oishi¹, Peiying Liu^1,4, Marilyn Albert³, and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Oxygen extraction fraction (OEF) has been suggested to be differentially affected by Alzheimer’s and vascular pathology in older adults. We aimed to investigate age-related OEF change with a longitudinal study design. 138 elderly participants were recruited with a 2-year follow-up. Individuals with higher vascular risks showed significant elevation in OEF but not those with lower vascular risks. Higher OEF was also associated with a faster growth in white matter hyperintensities, but not with any Alzheimer’s pathology or APOE gene. The results suggested a prominent effect of vascular pathology on OEF in aging.

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