Abstract #3985

Glymphatic System Evaluation in Obstructive Sleep Apnea Adults using Diffusion Tensor Imaging

Alba Nunez¹, Bhaswati Roy¹, Ravi S. Aysola², Daniel W Kang², and Rajesh Kumar^1,3,4,5

¹Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States, ²Medicine, University of California Los Angeles, Los Angeles, CA, United States, ³Radiological Science, University of California Los Angeles, Los Angeles, CA, United States, ⁴Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, ⁵Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States

Synopsis

OSA is characterized by recurrent episodes of complete or partial collapse of the upper airway during sleep, leading to sleep fragmentation. The altered sleep architecture can potentially hinder the extracellular waste removal system known, the glymphatic system, which is known for clearing interstitial solutes, including beta amyloids. In this study, we evaluated the glymphatic system using non-invasive MRI based diffusion tensor imaging data analyses along the perivascular space (DTI-ALPS) in OSA patients and healthy controls, and show impaired glymphatic system in the condition.

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