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Abstract #3986

Brain Ultrashort-T2* component measurements in patients with multiple sclerosis

Nikhil Deveshwar1,2, Eduardo Caverzasi1, Jingwen Yao1, Ari Green3, Roland Henry2,3, and Peder E. Z. Larson1,2
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley and San Francisco, CA, United States, 3Department of Neurology, University of California, San Francisco, San Francisco, CA, United States

Synopsis

This work presents a study measuring and characterizing the brain ultrashort-T2* component in patients suffering from MS. Our results show that the measured T2* relaxation time of the ultrashort-T2* component is significantly lower in almost all white matter ROIs measured. Fitted signal curves for the fractional component suggest the fractional component fits well in certain patients but not as well in others suggesting a more robust fitting model may be necessary for using this UTE relaxometry technique in patients with MS.

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