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Abstract #3988

Differences in functional connectivity in older adults with mild cognitive impairment and subjective cognitive decline

Arunan Srikanthanathan1, Susan Vandermorris1, Nicolaas Paul Verhoeff1, Jean Chen1, Nathan Herrmann2, and Linda Mah1
1Rotman Research Institute , Baycrest Health Sciences, North York, ON, Canada, 2Sunnybrook Research Institute, Toronto, ON, Canada


Subjective cognitive decline (SCD) is a preclinical stage of Alzheimer’s disease (AD) that may precede mild cognitive impairment (MCI), a prodrome of AD. We used resting-state functional magnetic resonance imaging to examine the pattern of functional connectivity in anterior brain regions that support memory processes in SCD and MCI. We found reduction of posterior cingulate cortex functional connectivity with medial temporal lobe structures in MCI and SCD, and associated increases in functional connectivity in the anterior brain regions, although direct group comparisons of the latter did not yield statistically significant differences.

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