Meeting Banner
Abstract #3989

Association between SFCI, a robust pathway-combined connectivity metric and neurological scores in multiple sclerosis

Pallab Bhattacharyya1, Robert Fox1, Jian Lin1, Ken Sakaie1, and Mark Lowe1
1Cleveland Clinic Foundation, CLEVELAND, OH, United States


Structural and functional connectivity index (SFCI) is a composite metric that combines structural and functional connectivity along different functionally specific pathways in multiple sclerosis. Performing functional connectivity and diffusion tensor imaging scans, we show that motor and cognitive pathway-combined SFCI is closely associated with multiple sclerosis functional composite, a composite neurological metric. Pathway-combined SFCI shows stronger association with MSFC than motor or cognitive pathway-specific composite metrics. Results from this study support the use of SFCI and composite pathway-based imaging measures as surrogate biomarkers for MS disease status and progression.

This abstract and the presentation materials are available to members only; a login is required.

Join Here