Motor and cognitive network integrity in multiple sclerosis over 2 years in patients receiving the same therapy was tracked using structural and functional connectivity index (SFCI), a metric that combines functional and structural connectivity along function-specific pathways and then forms a pathway-combined composite metric. Changes of the individual measures, functional connectivity and transverse diffusivity along transcallosal motor and frontoparietal cognitive pathways, were also tracked over 2 years. Pathway-combined SFCI was more efficient in tracking network integrity than the individual imaging measures or pathway-specific composite metric.
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