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Abstract #3991

Mapping of Early-Stage Changes in Cerebral Glutamate in APPNL-F/NL-F Mouse Model of Alzheimer’s Disease Using GluCEST MRI

Narayan Datt Datt Soni1, Ravi Prakash Reddy Nanga1, Juul Halvor1, and Ravinder Reddy1
1Department of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States


Alzheimer’s disease (AD) is characterized by progressive loss of cognitive abilities. Glutamate being the major excitatory neurotransmitter in mammalian brain, regulates various cognitive functions. Reports suggesting compromised cerebral glutamate homeostasis in AD indicates the potential of glutamate mapping in early diagnosis of AD. In the current study, we have used glutamate weighted Chemical Exchange Saturation Transfer (GluCEST) MRI to investigate changes in cerebral glutamate in 6-month-old APPNL-F/NL-F mouse model of AD. Our findings suggest reductions in the levels of cortical and hippocampal glutamate in APPNL-F/NL-F mice. A longitudinal study is ongoing to understand the pattern of perturbation with disease progression.

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