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Abstract #3992

Administration of ketone beta-hydroxybutyrate modulates 1H-MRS cortical GABA and Glu in healthy adults

Antoine Hone-Blanchet1, Botond Antal2, Liam McMahon1, Andrew Lithen1, Helena van Nieuwenhuizen2, Nathan Smith3, Alexander Lin1, Yi-Fen Yen1, Bruce Jenkins1, Liliane Mujica-Parodi2, and Eva Maria Ratai1
1Harvard Medical School/Massachusetts General Hospital, Boston, MA, United States, 2Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, 3Children's National Hospital, Washington D.C., DC, United States


Brain aging is highly correlated with deficiencies in glucose metabolism. Ketone beta-hydroxybutyrate (d-βHB) may represent an alternative fuel for energy metabolism in brain aging. This study assesses the neurochemical effect of an acute administration of d-βHB in the healthy human brain using MR spectroscopy. Results show that levels of GABA and Glu were significantly reduced in the posterior cingulate region after administration of d-βHB, but not glucose. Additionally, older age significantly predicted higher decreases in levels of both GABA and Glu. This suggests that administration of d-βHB alters normal cerebral metabolic profile in physiological brain aging.

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