Abstract #3994

Association of Fibroglandular Tissue ADC features on Diffusion-weighted MRI with Breast Cancer Risk

Wesley Surento¹, Anum S. Kazerouni², Janis Yee², Debosmita Biswas², Daniel S. Hippe³, Habib Rahbar², and Savannah C. Partridge²

¹Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, United States, ²Department of Radiology, University of Washington, Seattle, WA, United States, ³Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States

Synopsis

In this study, we investigated the association of fibroglandular tissue (FGT) apparent diffusion coefficient (ADC) measures with risk of breast cancer. Whole breast FGT regions were segmented on diffusion-weighted MRI (DWI) using a semi-automated fuzzy c-means-based algorithm. In high-risk screening cohort, ADC measures of FGT were compared in subjects with subsequent cancer diagnosis versus matched negative controls. Our findings indicate a modest negative association between FGT ADC and subsequent cancer diagnosis, with greater predictive value than mammographic density in the same cohort, pointing to the possible utility of DWI in the assessment of breast cancer risk.

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