In this study, we investigated the association of fibroglandular tissue (FGT) apparent diffusion coefficient (ADC) measures with risk of breast cancer. Whole breast FGT regions were segmented on diffusion-weighted MRI (DWI) using a semi-automated fuzzy c-means-based algorithm. In high-risk screening cohort, ADC measures of FGT were compared in subjects with subsequent cancer diagnosis versus matched negative controls. Our findings indicate a modest negative association between FGT ADC and subsequent cancer diagnosis, with greater predictive value than mammographic density in the same cohort, pointing to the possible utility of DWI in the assessment of breast cancer risk.
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