Histological validation of prostate tissue composition measurement using Hybrid Multidimensional MRI: Agreement with pathologists’ measures
Aritrick Chatterjee1,2, Tatjana Antic3, Alexander J Gallan4, Gladell P Paner3, Lawrence I-Kuei Lin5, Gregory S Karczmar1,2, and Aytekin Oto1,2
1Department of Radiology, University of Chicago, Chicago, IL, United States, 2Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy, Chicago, IL, United States, 3Department of Pathology, University of Chicago, Chicago, IL, United States, 4Department of Pathology, Medical College of Wisconsin, Medical College of Wisconsin, WI, United States, 5JBS Consulting Services Inc., Carlsbad, CA, United States
We validated prostate tissue composition measured using HM-MRI by comparing with reference standard results from pathologists’ interpretation of clinical histopathology slides following whole mount prostatectomy. We are 95% confident that 90% of absolute paired differences (TDI0.9) between HM-MRI and consensus results of pathologists were within 20.6% and 24.2% in measuring epithelium and lumen fractional volumes, respectively. These were less than our criterion of 30% and inter-pathologists’ agreement (22.3% for epithelium and 24.2% for lumen). Therefore, we accept the agreement performance of HM-MRI in measuring tissue composition measurement and consensus of pathologists is on par with the inter-raters (pathologists) agreement.
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