Abstract #4008

Histological validation of prostate tissue composition measurement using Hybrid Multidimensional MRI: Agreement with pathologists’ measures

Aritrick Chatterjee^1,2, Tatjana Antic³, Alexander J Gallan⁴, Gladell P Paner³, Lawrence I-Kuei Lin⁵, Gregory S Karczmar^1,2, and Aytekin Oto^1,2

¹Department of Radiology, University of Chicago, Chicago, IL, United States, ²Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy, Chicago, IL, United States, ³Department of Pathology, University of Chicago, Chicago, IL, United States, ⁴Department of Pathology, Medical College of Wisconsin, Medical College of Wisconsin, WI, United States, ⁵JBS Consulting Services Inc., Carlsbad, CA, United States

Synopsis

We validated prostate tissue composition measured using HM-MRI by comparing with reference standard results from pathologists’ interpretation of clinical histopathology slides following whole mount prostatectomy. We are 95% confident that 90% of absolute paired differences (TDI_0.9) between HM-MRI and consensus results of pathologists were within 20.6% and 24.2% in measuring epithelium and lumen fractional volumes, respectively. These were less than our criterion of 30% and inter-pathologists’ agreement (22.3% for epithelium and 24.2% for lumen). Therefore, we accept the agreement performance of HM-MRI in measuring tissue composition measurement and consensus of pathologists is on par with the inter-raters (pathologists) agreement.

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