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Abstract #4009

Renal mass assessment using Ultrashort Time-to-Echo sequences with ferumoxytol

Tianyi Zhou1, Liam Timms1, Aya Hamadeh2, David Drew3, Mukesh Harisinghani2, and Srinivas Sridhar1
1Department of Physics, Northeastern University, Boston, MA, United States, 2Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 3Tufts Medical Center, Boston, MA, United States


A ferumoxytol-enhanced MRA technique using Ultrashort Time-to-Echo (UTE) sequences is demonstrated for kidney vasculature mapping and renal mass assessment. The blood volume (BV) map is calculated by scaling the post- and pre-contrast subtraction image from 0 to 1. BV is measured in one cystic mass (-6±7)% and one complex mass (17±8)% with sub-regions BV up to (32±10)% and (30±7)%. The quantification of BV provides a measurement of the distribution of micro-vessel density, reflecting the vascularity of the kidneys and masses. This technique potentially benefits surgical planning, renal mass characterization, and disease progression in patients with impaired renal function.

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