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Abstract #4020

Whole-Abdomen Metabolic Imaging in Healthy Volunteers Using Hyperpolarized [1-13C]pyruvate MRI

Philip Meng-en Lee1, Hsin-Yu Chen1, Jeremy W Gordon1, Zhen J Wang1, Robert A Bok1, Kiersten Cheung1, Francesca De Las Alas1, Heather Daniel1, Peder EZ Larson1, Cornelius von Morze2, Daniel B Vigneron1, and Michael A Ohliger1
1Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Radiology, Washington University in St. Louis, St. Louis, MO, United States


Whole-abdomen imaging with hyperpolarized 13C is challenging due to B0 and B1 inhomogeneities, respiratory motion, and broad spatial coverage. There is also little baseline data about healthy metabolism in abdominal organs. We develop and describe a reliable imaging method to overcome these challenges, enabling metabolic imaging of the entire abdomen in a series of healthy volunteers. We establish normal values for conversion of HP [1-13C]pyruvate to lactate and alanine in key organs such as the liver, kidneys, pancreas, and spleen. Methods established here set a firm foundation for investigating a broad spectrum of metabolic and neoplastic abnormalities in the liver.

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