Abstract #4022

Quantifying Infant Lean Body Mass using Free-Breathing 3D Stack-of-Radial MRI

Hannah Parish¹, Shu-Fu Shih^2,3, Shahnaz Ghahremani³, Sevgi Gokce Kafali^2,3, Kara Calkins⁴, and Holden Wu^2,3

¹David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States, ²Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, ³Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ⁴Department of Pediatrics, University of California Los Angeles, Los Angeles, CA, United States

Synopsis

Lean body mass (LBM) is an important measure of metabolic ability. Decreased LBM during infancy may be associated with impaired growth and increased risk for future metabolic disease. This study measured skeletal muscle area as a surrogate for LBM in infants using free-breathing MRI. Psoas and paraspinal muscle areas were measured in 14 infants at the L4-L5 intervertebral disc level. Cross-sectional area of the thigh muscles was measured at the right midthigh in 8 infants. Infants with higher birth weights and those born large for gestational age had larger muscle areas than infants born lighter and/or small for gestational age.

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