Abstract #4028

Pancreatic PDFF in persons with obesity: change during weight loss and correlations with adipose tissue PDFF

Daniela Junker¹, Selina Rupp¹, Jessie Han¹, Mingming Wu¹, Anna Reik², Meike Wiechert², Hans Hauner^2,3, Marcus M. Makowski¹, Christina Holzapfel², and Dimitrios C. Karampinos¹

¹Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, ²Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany, ³Else Kroener-Fresenius-Center of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany

Synopsis

Risk stratification strategies in patients with metabolic diseases are urgently needed for the selection of appropriate lifestyle interventions. Pancreatic fat content has been shown to be associated with the metabolic syndrome and type 2 diabetes mellitus. MRI-based proton density fat fraction (PDFF) mapping based on a multi-echo gradient echo acquisition is the method of choice for non-invasive pancreatic fat quantification. This study evaluates how the PDFF of the pancreas correlates to adipose tissue PDFF and evolves after an 8-week weight loss intervention.

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