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Abstract #4028

Pancreatic PDFF in persons with obesity: change during weight loss and correlations with adipose tissue PDFF

Daniela Junker1, Selina Rupp1, Jessie Han1, Mingming Wu1, Anna Reik2, Meike Wiechert2, Hans Hauner2,3, Marcus M. Makowski1, Christina Holzapfel2, and Dimitrios C. Karampinos1
1Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, 2Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany, 3Else Kroener-Fresenius-Center of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany


Risk stratification strategies in patients with metabolic diseases are urgently needed for the selection of appropriate lifestyle interventions. Pancreatic fat content has been shown to be associated with the metabolic syndrome and type 2 diabetes mellitus. MRI-based proton density fat fraction (PDFF) mapping based on a multi-echo gradient echo acquisition is the method of choice for non-invasive pancreatic fat quantification. This study evaluates how the PDFF of the pancreas correlates to adipose tissue PDFF and evolves after an 8-week weight loss intervention.

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