Abstract #4029

Sex-differences in resting-state brain activity in children with concussion in comparison to matched healthy controls.

Bhanu Sharma^1,2,3, Carol DeMatteo^4,5, Michael D Noseworthy^1,3,6,7, and Brian W Timmons^2,5

¹Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, ²Child Health and Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, ON, Canada, ³Imaging Research Centre, St. Joseph's Healthcare, Hamilton, ON, Canada, ⁴School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada, ⁵CanChild Centre for Childhood Disability Research, McMaster University, Hamilton, ON, Canada, ⁶School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, ⁷Department of Radiology, McMaster University, Hamilton, ON, Canada

Synopsis

There are known sex-differences with respect to the clinical presentation of pediatric concussion, with girls reporting more symptoms and symptoms with greater severity than boys. This is the first study to show that there are also sex-differences in resting state brain activity in children with concussion, suggesting that the sex-specific clinical presentation may have neurological underpinnings. Specifically, girls with concussion had resting state disturbances that were not present in boys, which is consistent with the variable symptom presentation of the injury. Continued research into these resting state differences is encouraged.

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