Abstract #4029
Sex-differences in resting-state brain activity in children with concussion in comparison to matched healthy controls.
Bhanu Sharma1,2,3, Carol DeMatteo4,5, Michael D Noseworthy1,3,6,7, and Brian W Timmons2,5
1Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, 2Child Health and Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, ON, Canada, 3Imaging Research Centre, St. Joseph's Healthcare, Hamilton, ON, Canada, 4School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada, 5CanChild Centre for Childhood Disability Research, McMaster University, Hamilton, ON, Canada, 6School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, 7Department of Radiology, McMaster University, Hamilton, ON, Canada
Synopsis
There are known sex-differences with respect to the clinical presentation of pediatric concussion, with girls reporting more symptoms and symptoms with greater severity than boys. This is the first study to show that there are also sex-differences in resting state brain activity in children with concussion, suggesting that the sex-specific clinical presentation may have neurological underpinnings. Specifically, girls with concussion had resting state disturbances that were not present in boys, which is consistent with the variable symptom presentation of the injury. Continued research into these resting state differences is encouraged.
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