Abstract #4031

Mapping Brain Development in Infants and Young Children Using MPnRAGE T1 Relaxometry

Douglas Dean^1,2,3, Leela Shah³, Marissa DiPiero^3,4, Colleen Pletcher³, Lauren Heinrich³, Elizabeth Planalp³, Andrew Alexander^2,3,5, and Steven Kecskemeti³

¹Pediatrics, University of Wisconsin–Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin–Madison, Madison, WI, United States, ³Waisman Center, University of Wisconsin–Madison, Madison, WI, United States, ⁴Neuroscience Training Program, University of Wisconsin–Madison, Madison, WI, United States, ⁵Psychiatry, University of Wisconsin–Madison, Madison, WI, United States

Synopsis

Quantitative magnetic resonance imaging during the first years of life can provide novel insights into brain maturation, yet acquisition of these data are limited by challenges in imaging pediatric populations. Here, we assessed the self-navigated, motion robust MPnRAGE technique to acquire high-resolution T1-weighted structural brain images and quantitative T1 relaxometry maps in infants and young children. Our results demonstrate the ability to utilize MPnRAGE as a robust quantitative technique to assess early brain development.

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