The glymphatic system responsible for brain waste clearance may play an important role in aging and dementias. However, a lack of non-invasive tools for gauging glymphatic function in human subjects hindered the research on the age-related glymphatic changes. The global component of low-frequency (<0.1 Hz) resting-state fMRI signals was recently found coupled with CSF flow, and their coupling was used for quantifying the glymphatic function and found reduced significantly in neurodegenerative patients. Here we used the gBOLD-CSF coupling to evaluate glymphatic function change along healthy aging, and found it starts to decrease around age 55, particularly in females.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords