Meeting Banner
Abstract #4036

Gender-specific age-related changes in glymphatic function as measured by resting-state fMRI

Feng Han1, Yifan Yang1, and Xiao Liu1
1the Pennsylvania State University, State College, PA, United States


The glymphatic system responsible for brain waste clearance may play an important role in aging and dementias. However, a lack of non-invasive tools for gauging glymphatic function in human subjects hindered the research on the age-related glymphatic changes. The global component of low-frequency (<0.1 Hz) resting-state fMRI signals was recently found coupled with CSF flow, and their coupling was used for quantifying the glymphatic function and found reduced significantly in neurodegenerative patients. Here we used the gBOLD-CSF coupling to evaluate glymphatic function change along healthy aging, and found it starts to decrease around age 55, particularly in females.

This abstract and the presentation materials are available to members only; a login is required.

Join Here