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Abstract #4037

Limbic Predominant Age-related TDP-43 Encephalopathy Neuropathological Change (LATE-NC) is Associated with Lower Diffusion Anisotropy

Mahir Tazwar1, Arnold M. Evia2, Ashish A. Tamhane2, Abdur Raquib Ridwan1, David A. Bennett2, Julie A. Schneider2, and Konstantinos Arfanakis1,2
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States


The MRI signature of limbic predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) has not been fully determined. In this work, we investigated the association of diffusion anisotropy with LATE-NC in autopsied brains of community-based older adults (N=148). Voxel-wise analysis revealed an independent association of lower fractional anisotropy (FA) with greater LATE-NC burden in medial temporal lobe white matter, controlling for other neuropathologies. The white matter connections implicated include fibers connecting cortical and subcortical regions where LATE-NC is typically found. Comparison of FA values across LATE-NC stages revealed that FA may allow detection of LATE-NC in later stages of the disease.

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