Alzheimer’s disease (AD) is common neurodegenerative dementia. Though the disease has no cure, early intervention can help to maintain normal mental function and slow down the progression of the disease. Brain imaging, especially Magnetic Resonance Imaging (MRI) has been extensively used to characterize the location and progression of the disease. Diffusion MRI is a novel imaging technique that exploits the microscopic mobility of water molecules. However, a comprehensive study incorporating high-resolution diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and Neurite Orientation Dispersion and Density Imaging (NODDI) is still lacking. So, we aim to apply DTI, DKI and NODDI.
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