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Abstract #4038

Diffusion MRI in a transgenic mouse model of Alzheimer's disease

Surendra Maharjan1, Kaitlyn Marie Dybing1, and Nian Wang1
1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States


Alzheimer’s disease (AD) is common neurodegenerative dementia. Though the disease has no cure, early intervention can help to maintain normal mental function and slow down the progression of the disease. Brain imaging, especially Magnetic Resonance Imaging (MRI) has been extensively used to characterize the location and progression of the disease. Diffusion MRI is a novel imaging technique that exploits the microscopic mobility of water molecules. However, a comprehensive study incorporating high-resolution diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and Neurite Orientation Dispersion and Density Imaging (NODDI) is still lacking. So, we aim to apply DTI, DKI and NODDI.

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