Abstract #4040

Non-Gaussian Brain Diffusion Cross-sectional and Longitudinal Changes in Type 2 Diabetes Mellitus Adults

Bhaswati Roy¹, Daisy Mercado², Matthew J Freeby³, Sarah Choi², and Rajesh Kumar^1,4,5,6

¹Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States, ²UCLA School of Nursing, Los Angeles, CA, United States, ³Medicine, University of California Los Angeles, Los Angeles, CA, United States, ⁴Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ⁵Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, ⁶Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States

Synopsis

Patients with Type 2 diabetes mellitus (T2DM) show brain changes in mood and cognitive control sites, functions that are deficient in the condition, examined by Gaussian diffusion-based diffusion tensor imaging (DTI). However, the majority of brain areas with complex fibers, follow non-Gaussian diffusion, and DTI-based measures may not show adequate diffusion changes. We examined brain changes at baseline and 6 months in T2DM patients using the diffusion kurtosis imaging-based mean kurtosis procedures and showed wide-spread acute and chronic tissue changes in the condition, with continued progression after 6 months in areas involved in mood and cognitive regulatory functions.

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