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Abstract #4043

Evaluation of the Effects of Capsinoids on Brown Adipose Tissue Recruitment and Activation in Obesity Using PET/MRI

Jie Deng1, Lisa M Neff2, and Bin Zhang3
1Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States, 2Chicago, IL, United States, 3Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States


In this randomized, placebo-controlled trial in subjects with obesity, we implemented multi-parametric MRI including fat fraction (FF), R2*, and T1 values on PET-MRI in both thermoneutral and cold-activated non-shivering thermogenesis conditions to investigate whether brown adipose tissue property changes measured by MRI can reflect its activation secondary to cold-activated stimulation and chronic capsinoids ingestion before and after weight loss. In subjects taking capsinoids, FF decreased and R2* increased significantly after weight loss as compared with baseline, and these changes were significantly larger than the changes seen after weight loss in the group taking placebo.

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