T1ρ dispersion imaging based on repeated T1ρ measurements at multiple spin-lock frequencies allows characterization of different dynamic processes of tissues. The clinical potential of this techniques is however limited by the total scan time needed to obtain reliable and consistent quantitative measurements. In this work, we propose an unpaired, interleaved phase-cycling scheme for T1ρ dispersion imaging, which almost reduces total scan time by a half compared with the traditional paired PC approach. This method, when combined with other advanced imaging and reconstruction techniques, could potentially enable high-resolution T1rho dispersion imaging acquired within clinically acceptable scan duration.
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