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Abstract #4086

MR thermometry using fingerprinting: application to lead heating

Enlin Qian1, Pavan Poojar1, David H. Gultekin1, J. Thomas Vaughan1, Devashish Shrivastava1, Zhezhen Jin2, Brett E. Youngerman3, and Sairam Geethanath1
1Columbia Magnetic Resonance Research Center, Columbia University, New York, NY, United States, 2Department of Biostatistics, Columbia University, New York, NY, United States, 3Columbia University Irving Medical Center, Columbia University, New York, NY, United States


We explore the feasibility of noninvasive temperature measurement around deep brain stimulation (DBS) leads using magnetic resonance fingerprinting (MRF) by leveraging 1) the dependency of T1 on temperature; 2) MRF’s efficient T1 and B0 mapping. We conducted a T1 and temperature calibration experiment and a lead calorimetry experiment on bovine muscle. The effects of B0 inhomogeneity and temperature profiles of different regions of interest (ROI) were investigated. The calibration showed a strong correlation between temperature and T1 (R2>0.98). We observed a maximum change of 10.2 oC near leads (~1mm away) during calorimetry experiments, validated by fluoroptic probes.

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