Disposable, Handheld Clinical-Scale HP Propane Hyperpolarizer for Pulmonary MRI
Eduard Y Chekmenev1, Anna Samoilenko2, Jonathan R. Birchall2, Kirill V. Kovtunov3, Larisa M Kovtunova3, Valeriy I. Bukhtiyarov4, Igor V. Koptyug3, Chunqi Qian5, Boyd M Goodson6, and Nuwandi M. Ariyasingha2
1Chemistry and Oncology, Wayne State University, Detroit, MI, United States, 2Chemistry, Wayne State University, Detroit, MI, United States, 3International Tomography Center RAS, Novosibirsk, Russian Federation, 4Boreskov Institute of Catalysis RAS, Novosibirsk, Russian Federation, 5Radiology, Michigan State University, Lansing, MI, United States, 6Southern Illinois University Carbondale, Carbondale, IL, United States
We demonstrate a disposable and handheld hyperpolarizer for clinical-scale production of hyperpolarized propane gas for application as an inhalable contrast agent for pulmonary MRI. The device consists of an aluminum commercial spray can, which contains a mixture of pressurized propylene and parahydrogen gases. This filled container can be easily transported and stored for weeks. The hyperpolarized propane production is initialized by valve actuation, which releases the propylene-parahydrogen mixture into a mini-catalytic reactor producing a stream of pure (without catalyst) hyperpolarized propane gas on demand. The feasibility of 3 T EPI, FIESTA, and GRE MRI in hyperpolarized phantoms is demonstrated.
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