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Abstract #4089

In vivo pH Measurement by T2ex Relaxometry of Iodinated Contrast Agent and Comparison with CEST pH Imaging

Pietro Irrera1, Bruna Victorasso Jardim-Perassi1, Epifanio Ruiz2, Mikalai Budzevich2, Justin YC Lau2, and Robert J Gillies1
1Cancer Physiology, Moffitt Cancer Center, Tampa, FL, United States, 2Small Animal Imaging Laboratory, Moffitt Cancer Center, Tampa, FL, United States


This work is based on a well-known MRI property, the transverse relaxation changes of bulk water due to the presence of a solute with water-exchangeable protons. Many molecules can exhibit this ability to change water T2, such as glucose, urea, ammonium chloride, metals and paramagnetic complexes. Here we used the FDA-approved iodinated agent iopamidol (Isovue), widely used for CEST applications, as a T2ex agent to quantify pH in vitro and in vivo, since its –NH groups exhibit pH-dependent exchange rates with water protons. Computed tomography provided iopamidol concentrations to complement the MR relaxometry measurements, allowing determination of pH in vivo.

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