This work presents a multi vendor multi-site MRI study in which a TRUST sequence was harmonized across three MRI platforms from GE, Siemens, and Philips to measure the cerebral venous oxygenation Yv. We carried out intra-scanner and inter-scanner analysis on the variability of the venous oxygenation measurements and demonstrated high measurements reproducibility across the three platforms. Moreover, we examined the relationship between the fluctuations in end-tidal CO2 and the Yv measurements and showed that end-tidal CO2 can reduce the variability in Yv measurements in multi-site setting.
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