Measuring cerebral venous oxygenation: multi-site multi-vendor standardization of TRUST MRI and association with end-tidal CO2
Abubakr Eldirdiri1, Jiachen Zhuo1, Zixuan Lin2, Hanzhang Lu2,3,4, Rao Gullapalli1, and Dengrong Jiang2
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States
This work presents a multi vendor multi-site MRI study in which a TRUST sequence was harmonized across three MRI platforms from GE, Siemens, and Philips to measure the cerebral venous oxygenation Yv. We carried out intra-scanner and inter-scanner analysis on the variability of the venous oxygenation measurements and demonstrated high measurements reproducibility across the three platforms. Moreover, we examined the relationship between the fluctuations in end-tidal CO2 and the Yv measurements and showed that end-tidal CO2 can reduce the variability in Yv measurements in multi-site setting.
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