Abstract #4094

Comparison of Quantitative BOLD and Vascular MRF for Mapping Brain Oxygenation

Linh N N Le¹, Gregory J Wheeler¹, Thomas Christen², Greg Zaharchuk³, and Audrey P Fan ^1,4

¹Biomedical Engineering, University of California, Davis, Davis, CA, United States, ²Grenoble Institute of Neuroscience, Grenoble, France, ³Radiology, Stanford University, Palo Alto, CA, United States, ⁴Neurology, University of California, Davis, Davis, CA, United States

Synopsis

We compared two approaches of quantitative Blood-Oxygenation Level-Dependent (qBOLD) and vascular MR Fingerprinting (vMRF) to map brain oxygenation from Gradient-Echo Sampling of Free Induction Decay and Echo (GESFIDE) scans acquired during normoxic, hyperoxic, and hypoxic gas breathing conditions. In 12 healthy subjects, OEF calculated from qBOLD (qOEF) and OEF generated from vMRF (vOEF) were inversely correlated to pulse oxygenation (SaO₂) (p=0.032 and p=0.014, respectively), indicating that qBOLD and vMRF are reliable methods for brain oxygenation mapping.

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