Oxygen Extraction Fraction using Quantitative BOLD and Cerebral Blood Flow during Vasodilation
Linh N N Le1, Gregory J Wheeler2, Alique M Momjian2, Corinne A Donnay3, Nicholas P Blockley4, and Audrey P Fan2,3
1Biomedical Engineering, University of California, Davis, San Diego, CA, United States, 2Biomedical Engineering, University of California, Davis, Davis, CA, United States, 3Neurology, University of California, Davis, Davis, CA, United States, 4School of Life Sciences, University Of Nottingham, Nottingham, United Kingdom
We quantified brain oxygen extraction fraction (OEF) using quantitative Blood-Oxygenation Level-Dependent (qBOLD) modeling of asymmetric spin echo (ASE) scans acquired at baseline and after pharmacological vasodilation with acetazolamide. In 9 healthy subjects, 60.51±42.00% CBF elevation and -8.45±9.71% OEF decrease in response to vasodilation was observed in multiple gray matter regions in the cortex. The correlation between cerebral blood flow (CBF) and OEF was inversely proportional (p=0.02), indicating complementary vascular responses to the acetazolamide stimulus.
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