Abstract #4095

Oxygen Extraction Fraction using Quantitative BOLD and Cerebral Blood Flow during Vasodilation

Linh N N Le¹, Gregory J Wheeler², Alique M Momjian², Corinne A Donnay³, Nicholas P Blockley⁴, and Audrey P Fan^2,3

¹Biomedical Engineering, University of California, Davis, San Diego, CA, United States, ²Biomedical Engineering, University of California, Davis, Davis, CA, United States, ³Neurology, University of California, Davis, Davis, CA, United States, ⁴School of Life Sciences, University Of Nottingham, Nottingham, United Kingdom

Synopsis

We quantified brain oxygen extraction fraction (OEF) using quantitative Blood-Oxygenation Level-Dependent (qBOLD) modeling of asymmetric spin echo (ASE) scans acquired at baseline and after pharmacological vasodilation with acetazolamide. In 9 healthy subjects, 60.51±42.00% CBF elevation and -8.45±9.71% OEF decrease in response to vasodilation was observed in multiple gray matter regions in the cortex. The correlation between cerebral blood flow (CBF) and OEF was inversely proportional (p=0.02), indicating complementary vascular responses to the acetazolamide stimulus.

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