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Abstract #4096

MR-guided Focused Ultrasound of the Dorsal Root Ganglion for the Treatment of Low Back Pain: Preclinical Study in a Peripheral Nerve Injury Model

Viola Rieke1, Candace Floyd1, Allison Payne1, Henrik Odeen1, Matt Zabriskie1, Michelle Kline1, Rock Hadley1, Robb Merrill1, and Lubdha Shah1
1University of Utah, Salt Lake City, UT, United States


Many of the currently available low back pain (LBP) treatments are invasive with associated risks and complications. MR-guided Focused Ultrasound (MRgFUS) is a lower risk, completely non-invasive alternative modality. We developed a large animal chronic LBP model, induced by peripheral nerve injury, and evaluated the response with quantitative sensory testing (QST). Here we investigate the ability to decrease neuropathic LBP with FUS neuromodulation of the spinal dorsal root ganglion with MRgFUS. Our data suggest that the QST techniques are sensitive indicators of pain and that effects on pain reduction can be detected using this clinically relevant evaluation method.

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