Many of the currently available low back pain (LBP) treatments are invasive with associated risks and complications. MR-guided Focused Ultrasound (MRgFUS) is a lower risk, completely non-invasive alternative modality. We developed a large animal chronic LBP model, induced by peripheral nerve injury, and evaluated the response with quantitative sensory testing (QST). Here we investigate the ability to decrease neuropathic LBP with FUS neuromodulation of the spinal dorsal root ganglion with MRgFUS. Our data suggest that the QST techniques are sensitive indicators of pain and that effects on pain reduction can be detected using this clinically relevant evaluation method.