Abstract #4098

Imaging hypoxia in two brain tumor models using GdDO3NI

Babak Moghadas¹, Jonathan Scirone¹, Matthew Scarpelli², Alberto Fuentes², C. Chad Quarles², and Vikram D. Kodibagkar³

¹Arizona State University, Tempe, AZ, United States, ²Barrow Neurological Institute, Phoenix, AZ, United States, ³School of Biological and Systems Engineering, Arizona State University, Tempe, AZ, United States

Synopsis

In this study we have used the hypoxia-targeting MRI contrast agent GdDO3NI, (a nitroimidazole-based T1 contrast agent) to image the development of hypoxia in two types of rodent brain tumor models. Our results indicate a range of signal enhancements from 0-17% over baseline in the C6 and 9L tumors using GdDO3NI with clearance from contralateral brain and muscle tissue. This study further demonstrates the utility of GdDO3NI in non-invasive imaging of tissue hypoxia with high resolution.

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