Imaging hypoxia in two brain tumor models using GdDO3NI
Babak Moghadas1, Jonathan Scirone1, Matthew Scarpelli2, Alberto Fuentes2, C. Chad Quarles2, and Vikram D. Kodibagkar3
1Arizona State University, Tempe, AZ, United States, 2Barrow Neurological Institute, Phoenix, AZ, United States, 3School of Biological and Systems Engineering, Arizona State University, Tempe, AZ, United States
In this study we have used the hypoxia-targeting MRI contrast agent GdDO3NI, (a nitroimidazole-based T1 contrast agent) to image the development of hypoxia in two types of rodent brain tumor models. Our results indicate a range of signal enhancements from 0-17% over baseline in the C6 and 9L tumors using GdDO3NI with clearance from contralateral brain and muscle tissue. This study further demonstrates the utility of GdDO3NI in non-invasive imaging of tissue hypoxia with high resolution.
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