Due to their low cytoplasmic capacity and phagocytic activity, T cells have consistently been challenging to label for MR tracking applications. We developed a one-stop shop approach where the T cell sorting agent also labels the cells which can subsequently be imaged using non-invasive MRI. We demonstrate positive intracellular localization of the beads in Treg cells by means of histopathology analyses and MRI signal effects in phantoms containing different amounts of labeled cells.
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