Abstract #4127
T1ρ dispersion imaging on 3T MRI detects diffuse fibrosis in subtypes of hypertrophic cardiomyopathy
Keyan Wang1, Wenbo Zhang1, Shuman Li1, Hongrui Jin1, Yanan Jin1, Yanan Jin1, Li Wang2, Ran Li3, Yang Yang4, Jingliang Cheng1, Jie Zheng5, and Jing An6
1MRI department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2Pathology department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 3Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States, 4Icahn School of Medicine at Mount Sinai, New York, NY, United States, 5Washington University School of Medicine, Saint Louis, MO, United States, 6Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China
Synopsis
This study evaluated a cardiac T1ρdispersion mapping technique, termed as myocardial fibrosis index (mFI), to distinguish various levels of fibrosis in different subtypes of hypertrophic cardiomyopathy (HCM). These subtypes included patients with or without obstructive HCM, and with or without hypertrophic myocardial segments. Our data demonstrated that the mFI is equal to or significantly better than other cardiac fibrosis index, contrast-derived extracellular volumes, and native T1 values.
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