Abstract #4127

T1ρ dispersion imaging on 3T MRI detects diffuse fibrosis in subtypes of hypertrophic cardiomyopathy

Keyan Wang¹, Wenbo Zhang¹, Shuman Li¹, Hongrui Jin¹, Yanan Jin¹, Yanan Jin¹, Li Wang², Ran Li³, Yang Yang⁴, Jingliang Cheng¹, Jie Zheng⁵, and Jing An⁶

¹MRI department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²Pathology department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ³Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States, ⁴Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Washington University School of Medicine, Saint Louis, MO, United States, ⁶Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China

Synopsis

This study evaluated a cardiac T1ρdispersion mapping technique, termed as myocardial fibrosis index (mFI), to distinguish various levels of fibrosis in different subtypes of hypertrophic cardiomyopathy (HCM). These subtypes included patients with or without obstructive HCM, and with or without hypertrophic myocardial segments. Our data demonstrated that the mFI is equal to or significantly better than other cardiac fibrosis index, contrast-derived extracellular volumes, and native T1 values.

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