A two-stage cardiac PET/late gadolinium enhancement (LGE) co-registration method proposed here significantly improved the co-registration between PET and LGE in integrated PET/MR imaging. The two-stage method led to increased registration score (4.93±0.89) versus no-registration (3.49±0.84, p<0.001) and a single-stage method (4.23±0.81, p<0.001), an increased SUV value in the normal myocardium (3.87±2.56) compared with the no-registration (3.14±1.92, p<0.001) and the single-stage method (3.32±2.16, p<0.001). The technique may improve diagnostic accuracy of non-ischemic cardiomyopathies via better image co-registration.
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